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Medchemexpress LLC BAY-707 | 2109805-96-9 | 99.6% | 288.34 | 10 MG
Supplier: Medchemexpress LLC HY11208110MG
BAY-707 is a chemical probe that functions as a substrate-competitive, highly potent, and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. It exhibits a favorable pharmacokinetic profile compared to other MTH1 compounds and is well-tolerated in mice, though it does not demonstrate in vitro or in vivo anticancer efficacy.
- Substrate-competitive inhibitor of MTH1(NUDT1).
- Highly potent and selective (IC50 of 2.3 nM).
- Good pharmacokinetic profile.
- Well-tolerated in mice.
- Superior cellular target engagement (EC50 of 7.6 nM).
- High cell permeability (Caco-2 assay).
- Favorable physicochemical profile.
- Promising in vitro pharmacokinetic properties.
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