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Medchemexpress LLC BAY-707 | 2109805-96-9 | 99.6% | 288.34 | 10 MG
SDP

Catalog No. 5000436046
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BAY-707 is a chemical probe that functions as a substrate-competitive, highly potent, and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. It exhibits a favorable pharmacokinetic profile compared to other MTH1 compounds and is well-tolerated in mice, though it does not demonstrate in vitro or in vivo anticancer efficacy.

  • Substrate-competitive inhibitor of MTH1(NUDT1).
  • Highly potent and selective (IC50 of 2.3 nM).
  • Good pharmacokinetic profile.
  • Well-tolerated in mice.
  • Superior cellular target engagement (EC50 of 7.6 nM).
  • High cell permeability (Caco-2 assay).
  • Favorable physicochemical profile.
  • Promising in vitro pharmacokinetic properties.

Catalog No. 50-004-36046 Supplier Medchemexpress LLC Supplier No. HY11208110MG
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BAY-707 is a chemical probe that functions as a substrate-competitive, highly potent, and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. It exhibits a favorable pharmacokinetic profile compared to other MTH1 compounds and is well-tolerated in mice, though it does not demonstrate in vitro or in vivo anticancer efficacy.

  • Substrate-competitive inhibitor of MTH1(NUDT1).
  • Highly potent and selective (IC50 of 2.3 nM).
  • Good pharmacokinetic profile.
  • Well-tolerated in mice.
  • Superior cellular target engagement (EC50 of 7.6 nM).
  • High cell permeability (Caco-2 assay).
  • Favorable physicochemical profile.
  • Promising in vitro pharmacokinetic properties.

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