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Apexbio Technology LLC BAY 80-6946 (Copanlisib) 1032568-63-0 50mg
Supplier: Apexbio Technology LLC B217850
BAY 80-6946 (Copanlisib CAS number 1032568-63-0) is a small molecule inhibitor targeting class I phosphatidylinositol-3-kinase (PI3K) with potent inhibitory activity against PI3K- and PI3K- isoforms By blocking PI3K enzymatic activity Copanlisib interferes with downstream signaling pathways crucial for cell proliferation and survival In vitro studies demonstrate notable antiproliferative effects in cancer cell lines such as HuCCT-1 and EGI-1 (KRASG12D mutants) exhibiting IC50 values of approximately 147 nM and 137 nM respectively Clinical trials indicate potential utility in treating B-cell malignancies like chronic lymphocytic leukemia and non-Hodgkin lymphoma
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