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Medchemexpress LLC BB-Cl-Amidine | 1802637-39-3 | 98.2% | 459.97 | 10 MG
Supplier: Medchemexpress LLC HY11134710MM/1ML
BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor. It exhibits cytotoxicity in U2OS cells and has shown to improve endothelium-dependent vasorelaxation in MRL/lpr mice, subtly reducing splenomegaly and increasing anti-NET antibodies.
- Acts as a peptidylarginine deminase (PAD) inhibitor
- Exhibits cytotoxicity in U2OS cells with EC50/IC50 of 8.8 μM
- Significantly improves endothelium-dependent vasorelaxation in animal models
- Shows a strong trend towards downregulation of IRGs
- Subtly reduces splenomegaly and increases anti-NET antibodies
- Improves muzzle alopecia
- Soluble in various solvents including DMSO, SBE-β-CD in Saline, Corn Oil, and PEG300/Tween-80/Saline
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