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Apexbio Technology LLC Bcl Family Set I 1 Set
Supplier: Apexbio Technology LLC A99021
Bcl Family Set I is a small-molecule inhibitor targeting anti-apoptotic members of the Bcl-2 protein family including Bcl-2 Bcl-xL Bcl-w and Mcl-1 It is designed to inhibit these proteins thereby modulating apoptotic pathways Bcl Family Set I exerts its biological activity primarily through BH3-mimetic interactions that disrupt Bcl-2 family-mediated survival signaling ABT-737 selectively inhibits Bcl-2 Bcl-xL and Bcl-w WEHI-539 specifically antagonizes Bcl-xL TW-37 binds Bcl-2 Bcl-xL and Mcl-1 and ABT-263 (Navitoclax) targets Bcl-2 Bcl-xL and Bcl-w with low-nanomolar affinity Based on these pharmacological properties Bcl Family Set I holds research potential in apoptosis regulation and related biomedical studies
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