The Xpert BCR-ABL IS Panel C130 is intended for use as an assayed external quality control to monitor the performance of the in vitro quantitative detection of BCR-ABL1 translocation mRNA e14a2/b3a2 transcripts and the ABL1 endogenous control mRNA transcript when analyzed using the Xpert BCR-ABL Ultra assay on Cepheid GeneXpert Instrument Systems. Xpert BCR-ABL IS Panel C130 consists of six components. Each component contains an increasing concentration of BCR-ABL1 (e14a2/b3a2) RNA transcript mixed with a fixed concentration of ABL1 RNA transcript to produce six levels, 0.0%IS, 0.0032%IS, 0.01%IS, 0.1%IS, 1%IS and 10%IS, when analyzed on the GeneXpert system-Xpert BCR-ABL Ultra assay. Xpert BCR-ABL IS Panel C130 is comprised of 12 single use bottles, 2 bottles of each %IS level. The C130 bottles contain 4 mL of synthetic BCR-ABL1 RNA transcript and synthetic ABL1 control gene RNA transcript, suspended in a stabilizing matrix with a non-infectious solution of buffers and preservatives.