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Apexbio Technology LLC BD 1047 dihydrobromide 138356-21-5 10mg
Supplier: Apexbio Technology LLC B652110
BD 1047 dihydrobromide (CAS 138356-21-5) is a selective antagonist of the sigma-1 ( 1) receptor exhibiting Ki values of 0 93 nM for 1 and 47 nM for sigma-2 ( 2) receptors Sigma receptors distinct from opioid receptors include 1 and 2 subtypes and are implicated in modulating dopaminergic neurotransmission and drug-related behaviors In preclinical models BD 1047 dihydrobromide attenuates haloperidol- and DTG-induced dystonia and reverses cocaine-induced behavioral responses without affecting responses to natural rewards Additionally it alleviates mechanical allodynia in neuropathic pain models and modulates spinal 1 receptor and NR1 subunit expression This compound is utilized to investigate 1 receptor function in neuropharmacology and pain research
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