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BD Pharmingen™ IHC Zinc Fixative

Catalog No. BDB552658 Shop All BD Biosciences Products
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Description

An alternative to formalin fixation of tissue for paraffin embedded sections

Ten percent neutral buffered formalin fixes tissue by cross-linking proteins, potentially causing a conformational change or “masking” of the antigenic epitope and leading to reduced or absent antibody reactivity. Different antigen retrieval techniques are used to unmask the epitope; however, many times it is not possible to retrieve the epitope and get optimal immunohistochemical staining. In these situations the use of IHC Zinc fixative, which is a milder fixative than formalin, is recommended.

  • Zinc-fixed paraffin embedded sections show very good immunostaining with many leukocytes markers and depict tissue morphology comparable to formalin-fixation
  • Use of antigen retrieval techniques on the zinc-fixed paraffin sections may further enhance the antibody reactivity in some cases

There are a few antigens that are not preserved by zinc-fixation. In these situations use of fresh frozen tissue for immunohistochemical staining is the only alternative.

TRUSTED_SUSTAINABILITY

Specifications

Boiling Point 100°C
Color Clear
Content And Storage Room temperature
Dilution 10 X
Product Type Fixative
Quantity 500mL
For Use With (Application) Immunohistochemical staining
pH 7.2
Form Liquid
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