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Medchemexpress LLC BDP9066 | 2226507-04-4 | 98.18% | 348.44 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY111424100MG

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BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase (MRCK) inhibitor. It inhibits MRCKβ with an IC50 of 64 nM in SCC12 cells and has Ki values of 0.0136 nM for MRCKα and 0.0233 nM for MRCKβ. This compound demonstrates a therapeutic effect on skin cancer by reducing substrate phosphorylation.

  • Potent and selective inhibitor of MRCKα and MRCKβ.
  • Exhibits antiproliferative effects, particularly in hematologic cancer cells.
  • Inhibits MLC phosphorylation and blocks motility and invasion of SCC12 squamous cell carcinoma.
  • Topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes.

Catalog No. 50-003-44987


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