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Medchemexpress LLC BDP9066 | 2226507-04-4 | 98.2% | 348.44 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY11142450MG

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BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase (MRCK) inhibitor. It has an IC50 of 64 nM for MRCKβ in SCC12 cells, and Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β respectively (in house determinations). This compound demonstrates a therapeutic effect on skin cancer by reducing substrate phosphorylation.

  • Potent and selective MRCK inhibitor.
  • Therapeutic effect on skin cancer by reducing substrate phosphorylation.
  • Shows antiproliferative effects with greatest activity in hematologic cancer cells.
  • Inhibits MLC phosphorylation and blocks SCC12 squamous cell carcinoma motility and invasion.
  • Topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes.

Catalog No. 50-003-45824


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