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Cayman Chemical BelotecnhydrochlorIde 50mg

Supplier: Cayman Chemical 3548850 MG
A DNA topoisomerase I inhibitor (IC50 = 0.119 UG/ml); a derivative of camptothecin; inhibits the proliferation of KATO III, HT-29, A549, MDA-MB-231, and SKOV3 cells (IC50s = 160, 10.9, 9, 345, and 31 ng/ml, respectively); induces apoptosis and cell cycle arrest at the G2/M phase in, and inhibits invasion of, SiHa cells at 150 ng/ml; reduces tumor growth in a Ca Ski cervical cancer mouse xenograft model at 25 mg/kg; reduces food intake and body weight in pregnant dams and increases fetal deaths and decreases litter size at 80 UG/kg
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