Apexbio Technology LLC Bendamustine HCl 3543-75-7 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A19845.1

Bendamustine HCl (CAS 3543-75-7) is an alkylating agent that induces cytotoxicity primarily through DNA damage Mechanistically it disrupts the mitotic checkpoint by downregulating key regulators such as polo-like kinase 1 Aurora kinase A and cyclin B1 leading to mitotic failure and subsequent apoptosis In myeloma models bendamustine activates apoptosis signaling that involves ATM-mediated G2 cell cycle arrest cleavage of caspase-3 and mitochondrial apoptotic pathways It demonstrates dose-dependent antiproliferative activity in dexamethasone-sensitive (MM1 S IC50 119 8 M) and resistant (MM1 R IC50 138 M) multiple myeloma cell lines Bendamustine represents a useful research tool for studying DNA damage response and apoptosis in hematological malignancy contexts

Catalog No. 50-000-63489