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Medchemexpress LLC Bendamustine (hydrochloride) | 3543-75-7 | 99.89% | C16H22Cl3N3O2 | 100 MG
Supplier: Medchemexpress LLC HYB0077100MG
Bendamustine hydrochloride is a purine analogue and a DNA cross-linking agent that activates DNA-damage stress response and apoptosis. It possesses potent alkylating, anticancer, and antimetabolite properties.
- A purine analogue.
- Acts as a DNA cross-linking agent.
- Activates DNA-damage stress response.
- Induces apoptosis.
- Exhibits potent alkylating properties.
- Demonstrates anticancer effects.
- Possesses antimetabolite characteristics.
- Induces p21 (Cip1/Waf1) and NOXA genes.
- Increases the expression of p53 in SU-DHL-1 cells.
- Blocks mitotic checkpoints and causes mitotic catastrophe.
- Reduces the viability of multiple myeloma cell lines.
- Induces specific caspase-dependent multiple myeloma cell death.
- Inhibits the spindle-assembly checkpoint.
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