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Cayman Chemical BendamustInhydrochlorIde 50mg
Supplier: Cayman Chemical 2369350 MG
A DNA alkylating agent; inhibits growth of SKW-3, Reh, CML-T1, BV-173, and HL-60 leukemia cell lines (IC50s = 27.0, 28.6, 15.6, 20.8, and 57.7 μM, respectively) but not MCF-7 and MDA-MB-231 breast cancer cell lines (IC50s = >200 and >200 μM, respectively); kills B-CLL cells derived from naïve and bendamustine-pretreated patients (LD50s= 6.8-8.3 and 3.8-4.9 mg/ml, respectively); inhibits tumor growth by 9% and 96% alone and in combination with ofatumumab, respectively, in a JVM-3 CLL mouse xenograft model (50 mg/kg)
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