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Medchemexpress LLC Benzaldehyde-PEG4-azide | 1151451-77-2 | 97.0% | 323.34 | 1 G
Supplier: Medchemexpress LLC 1GHY133455
Benzaldehyde-PEG4-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a versatile click chemistry reagent due to its Azide group, enabling participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. PROTACs, which incorporate this linker, are designed to leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Facilitates selective degradation of target proteins via the ubiquitin-proteasome system
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