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Medchemexpress LLC Benzamide, 2,6-dichloro-n-[3-(1h-indol-5-yl)-1h-indazol-5-yl]- | 2249801-12-3 | 98.2% | 50 MG
SDP

Catalog No. 5000338861
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MD2-TLR4-IN-1 is an antagonist of the myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex. It inhibits Lipopolysaccharides (LPS)-induced expression of TNF-α and IL-6 in macrophages. This compound supports research into acute lung injury (ALI) and exhibits anti-inflammatory activity.

  • Inhibits NF-κB in RAW264.7 macrophages.
  • Directly binds to and disrupts MD2-TLR4 complex activation.
  • Suppresses NF-κB p65 subunit nuclear levels in LPS-induced macrophages.
  • Reduces macrophage infiltration and improves lung tissue histopathology in LPS-challenged mice.
  • Decreases airspace inflammation and LPS-induced myeloperoxidase (MPO) activity.
  • Lowers LPS-induced serum TNF-α levels and inflammatory mRNA levels in lung tissues.

Catalog No. 50-003-38861 Supplier Medchemexpress LLC Supplier No. HY12859850MG
May include imposed supplier surcharges.
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MD2-TLR4-IN-1 is an antagonist of the myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex. It inhibits Lipopolysaccharides (LPS)-induced expression of TNF-α and IL-6 in macrophages. This compound supports research into acute lung injury (ALI) and exhibits anti-inflammatory activity.

  • Inhibits NF-κB in RAW264.7 macrophages.
  • Directly binds to and disrupts MD2-TLR4 complex activation.
  • Suppresses NF-κB p65 subunit nuclear levels in LPS-induced macrophages.
  • Reduces macrophage infiltration and improves lung tissue histopathology in LPS-challenged mice.
  • Decreases airspace inflammation and LPS-induced myeloperoxidase (MPO) activity.
  • Lowers LPS-induced serum TNF-α levels and inflammatory mRNA levels in lung tissues.

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