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Medchemexpress LLC Benzamide, 4-butoxy-N-(2,4-difluorophenyl)- | 433967-28-3 | C17H17F2NO2 | 5 MG
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Supplier:  Medchemexpress LLC HY153935MG

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VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. It is inactive or very weakly antagonizing at other mGlu receptor subtypes, enhancing glutamate sensitivity of mGlu5 likely due to interaction at a site on the receptor distinct from the MPEP binding site.

  • Positive and highly selective mGlu5R allosteric modulator
  • EC50 of 33 nM for mGlu5 receptor
  • Inactive or very weakly antagonizing at other mGlu receptor subtypes
  • Enhances glutamate sensitivity of mGlu5
  • Does not bind at the MPEP allosteric site of mGlu5

Catalog No. 50-003-76524


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