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Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate (1:1) | 1336913-03-1 | 99.85% | 404.38 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY112217A10MM/1ML

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PSEM 89S TFA is a selective and brain-penetrant agonist for ion channels, orthogonally selective for Q79G and L141F. It is intended for research use only.

  • Activates layer 2/3 cortical neurons expressing PSAML141F,Y115F-5HT3 high conductance (HC).
  • Reversibly silenced transfected neurons by reducing cellular input resistance.
  • Strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F-glycine receptor (GlyR).
  • Shows good brain penetrance in mice after minimally invasive intraperitoneal administration.
  • Almost completely suppressed fos in ChR2-expressing neurons in male Agrp-cre mice.
  • Rises rapidly in serum and brain, and is mostly cleared from both compartments in 1 hour in C57BL/6 mice.

Catalog No. 50-004-38128


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