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Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate (1:1) | 1336913-03-1 | 99.85% | 404.38 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY112217A10MG

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PSEM 89S TFA is a selective and brain penetrant agonist for the resulting ion channels. It is orthogonally selective for Q79G and L141F, respectively. It is for research use only and not sold to patients.

  • Selective and brain penetrant agonist.
  • Orthogonally selective for Q79G and L141F.
  • Activates layer 2/3 cortical neurons expressing PSAML141F,Y115F-5HT3 high conductance (HC) at 10 or 30 μM.
  • Reversibly silenced transfected neurons by reducing cellular input resistance at 10 μM.
  • Strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F-glycine receptor (GlyR) (30 mg/kg).
  • Shows good brain penetrance in mice after minimally invasive intraperitoneal administration (30 mg/kg).

Catalog No. 50-004-38351


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