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![Medchemexpress LLC Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000366152-logo.png-650.jpg){kind=logo}
Medchemexpress LLC Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)- | 1020149-73-8 | 99.8% | 461.52 | 50 MG
Supplier: Medchemexpress LLC 50MGHY13962
SGI-1027 is a potent DNA methyltransferase (DNMT) inhibitor. It targets DNMT3B, DNMT3A, and DNMT1, exhibiting selective degradation of DNMT1 in various human cancer cell lines. The compound shows minimal cytotoxicity in rat hepatoma cells and does not induce apoptosis in these cells, while demonstrating antiproliferative activity and cytotoxicity against several human cell lines.
- DNA methyltransferase (DNMT) inhibitor
- Targets DNMT3B, DNMT3A, and DNMT1
- Selectively degrades DNMT1 in human cancer cell lines
- Low cytotoxicity in rat hepatoma cells
- Does not induce apoptosis in rat hepatoma cells
- Exhibits antiproliferative activity and cytotoxicity against various human cell lines
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