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Medchemexpress LLC Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)- | 838810-96-1 | 98.0% | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY130613

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MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). It demonstrates strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM) and functions as an antivirulence agent, effectively reversing β-lactam resistance in Methicillin-resistant strains (MRSA).

  • Potent synergism with cefuroxime
  • Reduces β-lactam MIC against S. aureus USA300
  • Enhances activity against S. aureus clinical isolates
  • Potentiates effects against various circulating MRSA strains
  • Synergizes with antimicrobial peptides colistin and polymyxin B
  • Inhibits mprF expression
  • Inhibits citrate-induced biofilm formation
  • Effective as monotherapy for MRSA-infected larvae
  • Increases survival in drug-treated larvae
  • Correlates with concentration-dependent bacterial killing

Catalog No. 50-003-39523


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