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Medchemexpress LLC Benzamil hydrochloride | 161804-20-2 | 99.7% | 5 MG
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Supplier:  Medchemexpress LLC HYB1546A5MG

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Benzamil hydrochloride, an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor with an IC50 of approximately 100 nM. It also functions as a non-selective blocker of Deg/epithelial sodium channels (ENaC) and can enhance myogenic vasoconstriction. It inhibits TRPP3-mediated Ca2+-activated currents with an IC50 of 1.1 μM.

  • Inhibits neuronal and heterologously expressed small conductance Ca2+-activated K-channels.
  • Treatment with the compound (0.7 mg/kg/day; s.c.) resulted in an average survival until 16.1 weeks of age in stroke-prone spontaneously hypertensive rats (SHRSP).

Catalog No. 50-004-11940


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