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Medchemexpress LLC Benzeneacetamide, 4-butoxy-N-hydroxy- | 2438-72-4 | 98.0% | 500 MG
Supplier: Medchemexpress LLC HYB0494500MG
Bufexamac is a selective IIb HDAC (HDAC6, HDAC10) and LTA4H dual inhibitor, demonstrating Kds of 0.53 μM for HDAC6 and 0.22 μM for HDAC10. It also functions as a nonsteroidal anti-inflammatory drug, useful in various research applications.
- Selective dual inhibitor of HDAC6, HDAC10, and LTA4H.
- Functions as a nonsteroidal anti-inflammatory drug.
- Inhibits IFN-α secretion in peripheral blood mononuclear cells.
- Inhibits HDAC10 to block autophagic flux, enhancing tumor-specific toxicity of DNA damage-inducing drugs.
- Inhibits neutrophil chemotaxis via inhibition of LTA4H-mediated endogenous LTB4 biosynthesis.
- Ameliorates LPS-induced acute lung injury in mice by targeting LTA4H.
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