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Medchemexpress LLC Benzeneacetamide, α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]- | 313254-51-2 | 99.35% | 449.55 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY167875MG

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ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker. It exhibits equipotent selectivity for human Nav1.1 and Nav1.3 subtypes, with IC50 values of 13 nM and 23 nM, respectively. The compound shows less potent inhibition of Nav1.2 (IC50=240 nM) and demonstrates 1,000-fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 μM). It is intended for research use only.

  • Targets voltage-gated sodium channels (Nav)
  • Equipotent for human Nav1.1 and Nav1.3 subtypes
  • Nanomolar potency
  • For research use only

Catalog No. 50-003-91150


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