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Medchemexpress LLC Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-, (αZ)- | 901787-88-0 | 98.0% | 451.28 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY19831A

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(Z)-4EGI-1 is the Z-isomer of 4EGI-1, functioning as an inhibitor of eIF4E/eIF4G interaction and translation initiation. It binds effectively to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM, and exhibits anticancer activity. In vitro studies with melanoma cells showed that treatment with (Z)-4EGI-1 significantly reduced the expression of regulatory proteins such as cyclin D1, cyclin E, and Survivin, while housekeeping proteins remained unaffected. It also inhibits the proliferation of cancer cells.

  • Functions as an inhibitor of eIF4E/eIF4G interaction and translation initiation.
  • Binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM.
  • Exhibits anticancer activity.
  • Reduces expression of regulatory proteins like cyclin D1, cyclin E, and Survivin.
  • Inhibits the proliferation of cancer cells with IC50 values of 15.3 μM for breast cells and 11.6 μM for melanoma cells.

Catalog No. 50-004-02178


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