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Medchemexpress LLC Benzenepropanoic acid, ß-(aminomethyl)-4-chloro-, hydrochloride (1:1) | 28311-31-1 | 99.8% | C10H13Cl2NO2 | 1 ML
Supplier: Medchemexpress LLC HYB0007C10MM/1ML
Baclofen hydrochloride is a lipophilic derivative of γ-aminobutyric acid (GABA) and an orally active, selective metabotropic GABAB receptor (GABABR) agonist. It mimics the action of GABA, producing slow presynaptic inhibition through the GABAB receptor. This compound exhibits high blood-brain barrier penetrance, making it suitable for muscle spasticity research.
- Orally active, selective GABAB receptor agonist.
- Mimics GABA action for slow presynaptic inhibition.
- Exhibits high blood-brain barrier penetrance.
- Increases cell viability in huntingtin-expressing striatal cells.
- Enhances chymotrypsin-like proteasome activity.
- Ameliorates motor deficits in Huntington's disease animal models.
- Reduces neuronal intranuclear inclusions in animal models.
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