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Apexbio Technology LLC Benzenesulfonamide 98-10-2 100mg
Supplier: Apexbio Technology LLC B6154100
Benzenesulfonamide (CAS 98-10-2) is an amide derivative of benzenesulfonic acid widely utilized as a synthetic intermediate for pharmaceuticals and other chemicals Mechanistically benzenesulfonamide derivatives have been investigated for their inhibitory activity against various human carbonic anhydrases (CAs) with certain 4-substituted diazo derivatives exhibiting strong binding affinity particularly for CA I and II isoforms as demonstrated by isothermal titration calorimetry and fluorescence-based thermal shift assays In in vivo models indole-based benzenesulfonamide derivatives show oral activity in rat and sheep models of airway inflammation attenuating physiological responses to antigenic or cholinergic challenge Benzenesulfonamide remains in preclinical evaluation
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