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Medchemexpress LLC Benzenesulfonamide, N-[(4-bromophenyl)methyl]-4-chloro-N-[(3R)-hexahydro-2-oxo-1H-aze | 851600-86-7 | 99.5% | C19H20BrClN2O3S | 100 MG
SDP

Supplier:  Medchemexpress LLC HY50882100MG

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ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor, demonstrating 51-fold selectivity for PS1 with EC50s of 12 nM for PS1 and 656 nM for PS2. It functions as a classic γ-secretase inhibitor, selectively inhibiting Aβ production over Notch signaling in cells. Oral administration *in vivo* leads to an acute reduction of brain Aβ in models of Alzheimer's disease.

  • Amyloid precursor protein (APP) selective γ-secretase inhibitor
  • Exhibits differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase
  • Demonstrates 51-fold selectivity for PS1
  • Selectively inhibits Aβ production over Notch signaling in cells
  • Displaces an active site directed inhibitor *in vitro*
  • Leads to acute reduction of brain Aβ *in vivo* in Alzheimer's disease models

Catalog No. 50-003-57703


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