Benzhydryl bromide, 90+%

Description

CAS: 776-74-9 | C13H11Br | 247.135 g/mol

Benzhydryl bromide is a halogenated building block. Benzhydryl group was preferred to the commoner benzyl to protect 2-nitrophenol in the Bartoli (vinyl Grignard) synthesis of 7-hydroxyindole. Protection was by reaction with the phenol in the presence of potassium carbonate in acetone; deprotection of the indole was by hydrogenolysis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Benzhydryl bromide is a halogenated building block. Benzhydryl group was preferred to the commoner benzyl to protect 2-nitrophenol in the Bartoli (vinyl Grignard) synthesis of 7-hydroxyindole. Protection was by reaction with the phenol in the presence of potassium carbonate in acetone; deprotection of the indole was by hydrogenolysis.

Solubility
Insoluble in water.

Notes
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents and bases. It is sensitive to moisture. Protect from humidity and water. Store under dry inert gas.

Specifications

Chemical Identifiers

• CAS: 776-74-9
• Molecular Formula: C13H11Br
• Molecular Weight (g/mol): 247.135
• MDL Number: MFCD00000134
• InChI Key: OQROAIRCEOBYJA-UHFFFAOYSA-N
• Synonym: bromodiphenylmethane, benzhydryl bromide, diphenylmethyl bromide, diphenylbromomethane, alpha-bromodiphenylmethane, bromo phenyl methyl benzene, benzene, 1,1'-bromomethylene bis, methane, bromodiphenyl, bromomethylene dibenzene, bromodiphenyl methane
• PubChem CID: 236603
• IUPAC Name: [bromo(phenyl)methyl]benzene
• SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)Br

• Melting Point: 36°C to 41°C
• Boiling Point: 183°C to 185°C (20 mmHg)
• Flash Point: >110°C (230°F)
• Odor: Pungent
• Quantity: 500 g
• UN Number: UN1770
• Beilstein: 638544
• Sensitivity: Moisture sensitive
• Solubility Information: Insoluble in water.
• Formula Weight: 247.14
• Percent Purity: ≥90%
• Chemical Name or Material: Benzhydryl bromide

Safety and Handling

Hazard Category	H314-H335
Hazard Statement	GHS H Statement H314-H318 Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statement	P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
DOTInformation	Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: DIPHENYLMETHYL BROMIDE
EINECSNumber	212-279-8
RTECSNumber	PA5350000
TSCA	Yes
Recommended Storage	Ambient temperatures; Store under Nitrogen

SDS

RUO – Research Use Only