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Cayman Chemical Benzisoxazole Hsp90 Inhibitor
Supplier: Cayman Chemical 1001269410 MG
An Hsp90 inhibitor (IC50 = 30 nM in a fluorescence polarization assay); selective for Hsp90 over a panel of kinases (IC50s = >20 µM); inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 µM, respectively); induces degradation of HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively (IC50 = 0.33 µM for both)
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