Medchemexpress LLC Benzoic acid, 3-fluoro-5-(2-pyridinyl)-, 2-[(2-fluorophenyl) sulfonyl] hydrazide | 2055397-28-7 | MFCD31690337 | 99.6% | 389.38 | 5 MG

Supplier:  Medchemexpress LLC 5MGHY102058

WM-1119 is a highly potent and selective KAT6A inhibitor, functioning as a chemical probe. It demonstrates anti-cancer efficacy both in vitro and in vivo by inhibiting MYST family histone acetyltransferases KAT6A and KAT6B. This compound induces cell cycle exit and cellular senescence without causing DNA damage, and it has shown to arrest tumor growth and significantly reduce tumor burden in animal models.

• Acts as a highly potent and selective KAT6A inhibitor
• Exhibits an IC50 of 0.25 μM for KAT6A in lymphoma cells
• Shows 1,100-fold greater activity against KAT6A than KAT5
• Demonstrates 250-fold greater activity against KAT6A than KAT7
• Induces cell cycle exit and cellular senescence in MEFs
• Inhibits the proliferation of EMRK1184 lymphoma cells
• Well-tolerated in in vivo studies without generalized ill effects

Catalog No. 50-003-64437