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Medchemexpress LLC Benzoic acid, 4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro [5.5]undec-9-yl]methyl]phenoxy]-, hydrochloride (1:1) | 461023-63-2 | 99.9% | 614.17 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY17450A10MM/1ML

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Aplaviroc hydrochloride, an SDP derivative, is a potent CCR5 antagonist. It exhibits strong activity against various HIV-1 strains, including wild-type and multidrug-resistant variants, by binding to CCR5 with high affinity and inhibiting gp120/CD4 binding. This compound has been shown to suppress R5 HIV-1 viremia in in vivo models.

  • Potent activity against three wild-type R5 HIV-1 strains (HIV-1Ba-L, HIV-1JRFL, and HIV-1MOKW).
  • Substantially more potent than previously published CCR5 inhibitors.
  • Suppresses infectivity and replication of two HIV-1MDR variants.
  • Binds to CCR5 with high affinity.
  • Potently blocks rgp120/sCD4 binding to CCR5.
  • Exerts potent anti-R5 human immunodeficiency virus type 1 effects in a novel AIDS mouse model.
  • Suppresses R5 HIV-1 viremia in hu-PBMC-NOG mice.

Catalog No. 50-003-86677


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