Benzotropine methanesulfonate

Description

Muscarinic receptor antagonist | CAS: 132-17-2 | C22H29NO4S | 403.54 g/mol

Benzotropine methanesulfonate is used to treat the symptoms of Parkinson?s disease and is currently in clincial trials for chronic back pain. It shows anti-muscarinic effects comparable to Atropine, and also demonstrates competitive anti-nicotinic action at the nAChR (nicotinic acetylcholine receptor).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in water (81 mg/ml at 25°C), DMSO (50 mg/ml at 25°C), ethanol (81 mg/ml at 25°C), and ether (very slightly).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents. Store at 4°C.

Specifications

Chemical Identifiers

• CAS: 132-17-2
• Molecular Formula: C22H29NO4S
• Molecular Weight (g/mol): 403.54
• MDL Number: MFCD00074784
• InChI Key: CPFJLLXFNPCTDW-STYNFMPRSA-N
• Synonym: benztropine mesylate, cogentin, benztropine mesilate, benztropine methanesulfonate, unii-wmj8tl7510, benztropine methylsulfonate, benzatropine mesilate, benzatropine mesylate, benzotropine mesylate, cobrentin methanesulfonate
• PubChem CID: 3246155
• IUPAC Name: (1R,5R)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane; methanesulfonic acid
• SMILES: CS(O)(=O)=O.CN1[C@@H]2CC[C@@H]1CC(C2)OC(C1=CC=CC=C1)C1=CC=CC=C1

• Melting Point: 135°C
• Color: White
• Quantity: 100 mg
• UN Number: UN2811
• Merck Index: 14,1121
• Solubility Information: Soluble in water (81mg/ml at 25°C),DMSO (50mg/ml at 25°C),ethanol (81mg/ml at 25°C),and ether (very slightly).
• Formula Weight: 403.54
• Physical Form: Solid
• Chemical Name or Material: Benzotropine methanesulfonate

Safety and Handling

Hazard Category	H301+H311-H330
Hazard Statement	GHS H Statement H301-H311-H331 Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled.
Precautionary Statement	P260-P264b-P270-P271-P280-P284-P301+P310-P302+P352-P304+P340-P310-P312-P330-P361-P363-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	205-048-8
RTECSNumber	YM3150000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only