Benzyloxyacetyl chloride, 95%

Description

CAS: 19810-31-2 | C9H9ClO2 | 184.619 g/mol

Benzyloxyacetyl chloride is a reagent used to construct substituted 2-azetidinones for further elaboration into annulated β-lactams. It is a commonly employed reagent for asymmetric synthesis of β-lactams. It is also used in preparation of (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile, key intermediate in the preparation of fluoroquinolone antibiotic for respiratory tract infections, non-racemic helicene and β-lactams.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Benzyloxyacetyl chloride is a reagent used to construct substituted 2-azetidinones for further elaboration into annulated β-lactams. It is a commonly employed reagent for asymmetric synthesis of β-lactams. It is also used in preparation of (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile, key intermediate in the preparation of fluoroquinolone antibiotic for respiratory tract infections, non-racemic helicene and β-lactams.

Solubility
Reacts with water.

Notes
It is sensitive to moisture. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature is 2 - 8°C. Store under inert gas.

Specifications

Chemical Identifiers

• CAS: 19810-31-2
• Molecular Formula: C9H9ClO2
• Molecular Weight (g/mol): 184.619
• MDL Number: MFCD00010768
• InChI Key: QISAUDWTBBNJIR-UHFFFAOYSA-N
• Synonym: benzyloxyacetyl chloride, 2-benzyloxy acetyl chloride, benzyloxy acetyl chloride, benzyloxyacetylchloride, benzyloxy-acetyl chloride, benzyloxyacetic acid chloride, acetyl chloride, phenylmethoxy, acetyl chloride, benzyloxy, alpha-benzyloxy acetyl chloride, bnoch2cocl
• PubChem CID: 177085
• IUPAC Name: 2-phenylmethoxyacetyl chloride
• SMILES: C1=CC=C(C=C1)COCC(=O)Cl

• Density: 1.189
• Boiling Point: 84°C to 87°C (0.4 mmHg)
• Flash Point: >110°C (230°F)
• Refractive Index: 1.523
• Linear Formula: C₆H₅CH₂OCH₂COCl
• Quantity: 25 g
• UN Number: UN3265
• Beilstein: 1947363
• Sensitivity: Moisture sensitive
• Solubility Information: Reacts with water.
• Formula Weight: 184.62
• Percent Purity: 95%
• Chemical Name or Material: Benzyloxyacetyl chloride

Safety and Handling

Hazard Category	H314-H335
Hazard Statement	GHS H Statement H314-H318 Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statement	P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
DOTInformation	Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only