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Medchemexpress LLC Berubicin hydrochloride | 293736-67-1 | 95.1% | 670.10 | 1 MG
Supplier: Medchemexpress LLC HY14942A1MG
Berubicin hydrochloride is an analog of Doxorubicin that can cross the blood-brain barrier. It inhibits P-gp and MRP1-mediated efflux and suppresses glioblastoma multiforme (GBM). This product exerts toxic effects on leukemia cells by activating nuclear factor κB (NF-κB) and induces apoptosis in neuroblastoma cells. It can be used in the study of tumors related to the nervous system.
- Crosses the blood-brain barrier
- Inhibits P-gp and MRP1-mediated efflux
- Suppresses glioblastoma multiforme (GBM)
- Activates nuclear factor κB (NF-κB)
- Induces apoptosis in neuroblastoma cells
- More potent activity than Doxorubicin in activating NF-κB and inhibiting DNA synthesis
- Prolongs survival time in intracranial orthotopic glioma models in mice
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