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Medchemexpress LLC Bestatin hydrochloride | 65391-42-6 | 99.9% | 1 ML
Supplier: Medchemexpress LLC HYB0134A10MM/1ML
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, primarily employed in cancer research. It demonstrates significant effects on cell differentiation, proliferation, and enzymatic activities both in vitro and in vivo.
- Inhibits CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase.
- Enhances ATRA-induced differentiation in ATRA-sensitive APL NB4 cells.
- Inhibits ATRA-driven phosphorylation of p38 MAPK.
- Slows cell cycle progression, reduces cell growth, and decreases cell division frequency.
- Significantly reduces CD13 expression in diabetic mice.
- Inhibits expression of VEGF and heparanase in diabetic mice.
- Increases the number of splenocytes producing hemolytic anti-SRBC antibodies in vivo.
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