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Cayman Chemical BestatInhydrochlorIde 100mg
Supplier: Cayman Chemical 70520100 MG
An aminopeptidase inhibitor; inhibits aminopeptidase B (IC50 = 0.05 UG/ml), aminopeptidase N (IC50 = 16.9 µM), leucine aminopeptidase (IC50 = 0.01 UG/ml), and the aminopeptidase activity of LTA4 hydrolase (Kapp = 172 nM); selective for these aminopeptidases over aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, and thermolysin; inhibits LTB4 production in erythrocytes at 70 µM; increases the expression of Akt, inhibits proliferation, migration, and invasion, and induces autophagy and apoptosis in 5637 bladder cancer cells; decreases serum levels of LTB4 and reduces tumor growth in a PDX mouse model of colorectal cancer at 5 and 15 mg/kg
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