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Medchemexpress LLC BETd-246 100mg | 2140289-17-2 | 946.02 g/mol | C48H55N11O10 | 100 MG
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Supplier:  Medchemexpress LLC HY115568100MG

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BETd-246 is a second-generation PROTAC-based BET bromodomain degrader that links Cereblon and BET ligands to induce selective degradation of BRD2, BRD3, and BRD4. It is intended for research use in biochemical, cell-based, and preclinical studies and has supporting solubility, purity, and activity data suitable for experimental applications.

  • Second-generation PROTAC degrader targeting BET family proteins (BRD2/BRD3/BRD4).
  • High reported purity of 98.34%.
  • Molecular weight 946.02 g/mol.
  • Soluble in DMSO at 200 mg/mL; in vivo formulation example: 10% DMSO/90% corn oil (≥ 5 mg/mL).
  • Demonstrates potent cellular activity (e.g., MDA-MB-468 IC50 < 10 nM; Burkitt's lymphoma GI50 0.4 μM).
  • Recommended storage: -20°C under nitrogen; in solvent: -80°C (6 months) or -20°C (1 month).
  • Available in research-scale quantities including 100 mg.

Catalog No. 50-002-26637


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