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Cayman Chemical BevntololhydrochlorIde 100mg
Supplier: Cayman Chemical 29792100 MG
A β1-AR antagonist (Ki = 14.79 nM in rat cortical membranes); selective for β1- over β2-ARs (Ki = 588.84 nM), as well as α2-ARs up to 100 μM, but is an antagonist of α1-ARs (Ki = 125.89 nM); inhibits LVA-ICa in dissociated rat ventro-medial hypothalamic neurons (IC50 = 40 μM); inhibits norepinephrine-induced contraction of isolated rabbit thoracic aorta (pA2 = 4.77), isoprenaline-induced inotropic effects in isolated guinea pig right atria (pA2 = 7.74), and isoprenaline-induce relaxation of isolated guinea pig trachea (pA2 = 6.69); prevents immobilization stress-induced increases in systolic blood pressure in a rat model of stress-induced hypertension at 250 mg/kg per day
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