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Medchemexpress LLC Bh3i-1 | 300817-68-9 | MFCD03453544 | 98.0% | 400.31 | C15H14BrNO3S2 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY100383100MG

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BH3I-1 is a small-molecule antagonist of the Bcl-2 family that disrupts BH3-domain interactions. Reported activities include inhibition of Bak BH3 binding to Bcl-xL (Ki 2.4 ±0.2 μM), binding to the p53/MDM2 pair (Kd 5.3 μM), and NMR evidence of targeting the BH3-binding pocket (Ki 7.8 ±0.9 μM). Supplied at ~98% purity for research use.

  • Inhibits Bak BH3 peptide binding to Bcl-xL (Ki ≈2.4 μM).
  • Binds p53/MDM2 with a reported Kd of 5.3 μM.
  • Targets the BH3-binding pocket of Bcl-xL (NMR Ki ≈7.8 μM).
  • High purity suitable for biochemical and cellular studies.
  • Available in small-scale quantities for laboratory use.

Catalog No. 50-002-13532


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