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Medchemexpress LLC Bi-0115 | 4929-23-1 | 99.7% | 287.74 | 1 ML
Supplier: Medchemexpress LLC HY2399910MM/1ML
BI-0115 is a selective inhibitor of LOX-1 (IC50=5.4 μM) that blocks the cellular uptake of oxLDL. Its binding triggers receptor inhibition by forming dimers of the homodimeric ligand binding domain. It efficiently reduces oxLDL internalization in the cellular context, with IC50 values (5.4 μM) that align well with determined Kd values in SPR (4.3 μM) and ITC (6.99 μM).
- Selective inhibitor of LOX-1 (IC50=5.4 μM).
- Blocks cellular uptake of oxLDL.
- Triggers receptor inhibition by forming dimers of the homodimeric ligand binding domain.
- Available for research use only.
- Can be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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