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Medchemexpress LLC Bi-0115 | 4929-23-1 | 99.7% | 287.74 | 25 MG
Supplier: Medchemexpress LLC 25MGHY23999
BI-0115 is a selective inhibitor of LOX-1 (IC50=5.4 μM) that blocks cellular uptake of oxLDL. Its binding triggers receptor inhibition by forming dimers of the homodimeric ligand binding domain.
- Selective inhibitor of LOX-1.
- Blocks cellular uptake of oxLDL.
- Binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain.
- Efficiently reduces oxLDL internalization in the cellular context with IC50 values (5.4 μM) in good agreement with determined Kd values in SPR (4.3 μM) and ITC (6.99 μM).
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