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Medchemexpress LLC BI-0474 | 2750570-55-7 | 99.8% | 587.74 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY14827810MM/1ML

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BI-0474 is a potent inhibitor of KRASG12C, exhibiting an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. This compound demonstrates significant anti-proliferative activity against NCI-H358 cells carrying the G12C mutation and shows promising anti-tumor efficacy in non-small cell lung cancer xenograft models.

  • Potent KRASG12C inhibitor
  • IC50 value of 7.0 nM for GDP-KRAS::SOS1 protein-protein interaction
  • Anti-proliferative activity against NCI-H358 cells with G12C mutation (EC50 26 nM)
  • Anti-tumor activity in non-small cell lung cancer xenograft models

Catalog No. 50-003-62352


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