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Medchemexpress LLC BI-0474 | 2750570-55-7 | 99.8% | 587.74 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY148278100MG

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BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It demonstrates significant anti-proliferative activity against NCI-H358 cells carrying the G12C mutation and shows favorable anti-tumor activity in non-small cell lung cancer xenograft models.

  • Potent KRASG12C inhibitor
  • Inhibits GDP-KRAS::SOS1 protein-protein interaction with an IC50 of 7.0 nM
  • Exhibits anti-proliferative activity against NCI-H358 cells with G12C mutation
  • Shows anti-tumor activity in non-small cell lung cancer xenograft models
  • Induces programmed cell death in xenograft models

Catalog No. 50-003-61227


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