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Medchemexpress LLC BI-0474 | 2750570-55-7 | 99.8% | 587.74 | 50 MG
Supplier: Medchemexpress LLC HY14827850MG
BI-0474 is a potent KRASG12C inhibitor that demonstrates an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation and shows good anti-tumour activity in non-small cell lung cancer xenograft models. Designed by Boehringer Ingelheim, this compound is available for research use only.
- Potent KRASG12C inhibitor
- IC50 value of 7.0 nM for GDP-KRAS::SOS1 protein-protein interaction
- Demonstrates anti-proliferative activity against NCI-H358 cells with G12C mutation
- Shows anti-tumour activity in non-small cell lung cancer xenograft models
- For research use only
- Purity of 99.83%
- Molecular weight of 587.74
- Chemical formula is C30H37N9O2S
- Appears as a white to off-white solid
- Target: KRAS-SOS1
- EC50 = 26 nM on NCI-H358 cells (G12C mutant)
- Soluble in DMSO at 100 mg/mL
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