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Medchemexpress LLC BI-0474 | 2750570-55-7 | 99.8% | 587.74 g·mol-1 | C30H37N9O2S | 10 MG
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Supplier:  Medchemexpress LLC HY14827810MG

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BI-0474 is a covalent KRAS G12C inhibitor research compound with potent biochemical and cellular activity, suitable for preclinical evaluation of KRAS G12C-driven cancers. It exhibits low-nanomolar biochemical potency, cellular antiproliferative effects, and has demonstrated antitumor activity in in vivo xenograft models.

  • Potent covalent KRAS G12C inhibitor.
  • Low-nanomolar biochemical potency (IC50 ≈ 7.0 nM).
  • Cellular antiproliferative activity (EC50 ≈ 26 nM in NCI-H358 cells).
  • Demonstrated antitumor efficacy in xenograft models.
  • High reported purity (99.83%).
  • Molecular formula C30H37N9O2S and molecular weight 587.74 g·mol-1.
  • Solid, white to off-white appearance suitable for research use.

Catalog No. 50-002-87116


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