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Medchemexpress LLC BI-1622 | 2681392-19-6 | 99.0% | 508.53 | 25 MG
SDP

Catalog No. 5000360390
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BI-1622 is a potent and highly selective orally active HER2 (ERBB2) inhibitor. It demonstrates significant selectivity over EGFR and has shown high antitumor efficacy in preclinical studies. The compound exhibits a favorable agent metabolism and pharmacokinetics profile.

  • Potent and selective HER2 (ERBB2) inhibitor
  • Exhibits an IC50 of 7 nM for HER2
  • Shows over 25-fold selectivity for HER2 over EGFR
  • Demonstrates high antitumor efficacy in xenograft mouse tumor models
  • Features good permeability and no PgP-mediated efflux liability
  • Has good in vitro clearance in mouse liver microsomes and hepatocytes
  • Inhibits proliferation of HER2-dependent cell lines
  • Induces a dose-dependent decrease in pHER2 and pERK levels

Catalog No. 50-003-60390 Supplier Medchemexpress LLC Supplier No. 25MGHY150023
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BI-1622 is a potent and highly selective orally active HER2 (ERBB2) inhibitor. It demonstrates significant selectivity over EGFR and has shown high antitumor efficacy in preclinical studies. The compound exhibits a favorable agent metabolism and pharmacokinetics profile.

  • Potent and selective HER2 (ERBB2) inhibitor
  • Exhibits an IC50 of 7 nM for HER2
  • Shows over 25-fold selectivity for HER2 over EGFR
  • Demonstrates high antitumor efficacy in xenograft mouse tumor models
  • Features good permeability and no PgP-mediated efflux liability
  • Has good in vitro clearance in mouse liver microsomes and hepatocytes
  • Inhibits proliferation of HER2-dependent cell lines
  • Induces a dose-dependent decrease in pHER2 and pERK levels

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