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Medchemexpress LLC BI 2536 | 755038-02-9 | 99.92% | C28H39N7O3 | 1 ML
Supplier: Medchemexpress LLC HY5069810MM/1ML
BI 2536 is a dual inhibitor targeting PLK1 and BRD4, with IC50 values of 0.83 nM and 25 nM respectively. It is known to suppress IFNB (encoding IFN-β) gene transcription and induces mitotic arrest and apoptosis in various human cancer cell lines. This compound has been shown to inhibit tumor growth in vivo and exhibits good blood-brain barrier permeability, causing mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells.
- Inhibits PLK1 and BRD4.
- Suppresses IFNB gene transcription.
- Induces mitotic arrest and apoptosis in cancer cells.
- Inhibits tumor growth in vivo.
- Exhibits blood-brain barrier permeability.
- Used in Western blot, immunofluorescence, and growth inhibition assays.
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