Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000376152

Medchemexpress LLC BI-2865 | 2937327-93-8 | C23H27N7O2S | 1 MG
SDP

Supplier:  Medchemexpress LLC HY1537241MG

Encompass_Preferred

BI-2865 is a non-covalent pan-KRAS inhibitor. It binds to wild-type (WT) and several mutant KRAS forms, including G12C, G12D, G12V, and G13D, with KDs ranging from 4.3 to 32 nM. This compound effectively inhibits the proliferation of G12C, G12D, or G12V mutant KRAS expressing BaF3 cells, showing a mean IC50 of approximately 140 nM.

  • Binds to multiple KRAS mutants (WT, G12C, G12D, G12V, G13D)
  • Inhibits proliferation of KRAS mutant expressing BaF3 cells
  • Derivative with a prolinol substituent and a pyrimidine linker
  • Exhibits direct ionic interaction with E62 and a water-mediated hydrogen bond network

Catalog No. 50-003-76152


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.