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Medchemexpress LLC BI-2865 | 2937327-93-8 | C23H27N7O2S | 25 MG
Supplier: Medchemexpress LLC 25MGHY153724
BI-2865 is a non-covalent pan-KRAS inhibitor that binds to wild-type and various mutant KRAS proteins. It effectively inhibits the proliferation of KRAS-expressing cells, making it suitable for research into KRAS-driven cancers and related pathways.
- Non-covalent pan-KRAS inhibitor
- Binds to WT, G12C, G12D, G12V, and G13D mutant KRAS
- Inhibits proliferation of G12C, G12D, or G12V mutant KRAS expressing BaF3 cells
- High purity (99.65%)
- Molecular weight: 465.57
- Derivative with a prolinol substituent and a pyrimidine linker
- Exhibits direct ionic interaction with E62
- Forms a water-mediated hydrogen bond network with R68 and Q61
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