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Medchemexpress LLC BI-3231 | 2894848-07-6 | 99.8% | 380.37 | 50 MG
Supplier: Medchemexpress LLC HY14881450MG
BI-3231 is a potent and selective chemical probe that inhibits hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), with IC50 values of 1 nM for hHSD17B13 and 13 nM for mHSD17B13. It is being researched for its potential in treating nonalcoholic steatohepatitis (NASH) and other liver diseases.
- Potent and selective hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) inhibitor
- Demonstrates high metabolic stability in liver microsomes
- Moderate metabolic stability in hepatocytes
- Significant hepatic exposure maintained over 48 hours
- Potential for research into nonalcoholic steatohepatitis (NASH) and other liver diseases
- Powder storage: -20°C for 3 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Solubility in DMSO: 125 mg/mL (328.63 mM)
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